Our scientific research

A study from 2013 published in the journal, “Reproductive Biology and Endocrinology” describes the techniques used to collect egg cells during IVF-Naturelle® treatment. We were able to show that flushing the follicle increases the yield of egg cells and that three flushing steps are needed to achieve the maximum egg cell yield. Based on this, follicles are often additionally flushed during follicular puncture in IVF-Naturelle centres.

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A study from 2014, published in the "Journal of Reproductive Medicine“compared the number of visits necessary for IVF-Naturelle® treatment and traditional  IVF treatment, as well as the costs and time necessary for each pregnancy achieved.

According to this study, the costs (for the centre!) per realised pregnancy are 15% lower for IVF-Naturelle© than for traditional IVF treatment. This only happens when IVF-Naturelle® is carried out with the specified minimum number of visits and the pregnancy rates achieved by Bern. The time required until a pregnancy occurs is nevertheless 30% higher. The study also shows that 69% of patients found follicular puncture during IVF-Naturelle© to be less uncomfortable than for traditional IVF, even though no anaesthetic or painkillers are given during IVF-Naturelle®. The calculated costs should of course not be seen as a direct benchmark for the price of IVF-treatment, as an IVF centre has other considerable costs to cover, which are not described in the publication.

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A study from 2014, published in "Reproductive Biomedicine Online", compares one of our IVF-Naturelle© treatments with low-dose administration of clomiphene citrate with IVF in a natural cycle without clomiphene citrate and examines their success parameters.

According to this study, we were able to show that the treatment with clomiphene citrate we developed had a much lower risk of premature ovulation despite only 1.1 visits prior to follicular puncture (follicle monitoring) and thus a significantly increased probability of transfer and pregnancy per treatment cycle. There were no side effects from the drugs used in almost all cases.

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A study from 2014, published in the journal “Human Reproduction”, shows that the composition of a follicle which developed under gonadotrophin stimulation (as in traditional IVF-treatment) contains significantly less proteins which are prognostically relevant for a pregnancy than a follicle which matured without any hormonal stimulation. It was particularly noticeable that the so-called Anti-Muellerian hormone (AMH), which is regarded a marker for a high probability of pregnancy, is about 3x more concentrated in a naturally matured follicle than in a follicle which matured under high-dose gonadotrophin stimulation.

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A 2017 study published in the journal "Acta Obstetrica Gynaecologica Scandinavica" showed that the psychological stress on women undergoing 3 IVF-Naturelle® cycles was lower than when undergoing traditional IVF treatment with high-dose hormone stimulation. Both the treatment-associated stress markers and the depression markers developed during treatment in favour of IVF-Naturelle®.

A study from 2017, published in the journal "Reproductive Biomedicine Online" has shown that the daily administration of progesterone after egg collection during IVF-Naturelle® is not necessary in most cases. This makes the treatment even more acceptable.

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In a study from 2017, which is currently being prepared for publication, we have clearly itemised prognostic factors for the success of IVF in a natural cycle. The highest success rates were among couples where the woman was younger than 35 years of age and sterility had only been recognised for 1-2 years.